HMG-CoA reductase inhibitor (hydrophilic statin)
Pravastatin sodium
Brand names: Lipostat
Adult dose
Dose: 10–40mg PO ON
Route: PO
Frequency: ON
Dose adjustments
Renal
Reduce in severe renal impairment
Clinical pearls
- Lower-potency hydrophilic statin — fewer drug interactions, useful in transplant patients
- 2nd-line per NICE NG181 (atorvastatin first-line)
Contraindications
- Active liver disease
- Pregnancy/breastfeeding
- Hypersensitivity
Side effects
- Myalgia
- Rhabdomyolysis (rare)
- Transaminitis
- GI upset
- Headache
Interactions
- Ciclosporin
- Fibrates (gemfibrozil — avoid)
- Erythromycin
Monitoring
- LFTs
- CK if symptomatic
- Lipids
Reference: BNF; NICE NG181; https://bnf.nice.org.uk/drugs/pravastatin-sodium/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Framingham Risk Score · Cardiovascular Risk
- ACC/AHA Pooled Cohort Equations — ASCVD Risk · Cardiovascular Risk
- PREVENT Cardiovascular Risk Calculator (AHA/ACC 2023) · Cardiovascular Risk
- Reynolds Risk Score for Women · Cardiovascular Risk
- SCORE2 — 10-Year CVD Risk (Age 40–69) · Cardiovascular Risk
- SCORE2-OP — 5/10-Year CVD Risk (Age ≥ 70) · Cardiovascular Risk
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines