Cardiology General Medicine

SCORE2 — 10-Year CVD Risk (Age 40–69)

European Heart Score 2 — estimates 10-year risk of fatal and non-fatal cardiovascular events for adults aged 40–69 without known CVD or diabetes.

Sex*

Age (years, 40–69 for SCORE2)*(years)

Current smoker*

Systolic Blood Pressure (mmHg)*(mmHg)

Total cholesterol (mmol/L)*

HDL cholesterol (mmol/L)*

European CVD Risk Region*

Score interpretation

Low-to-moderate risk (all ages 40–69) 0–2.49

SCORE2 below 2.5 %: low-to-moderate risk at any age 40–69 (ESC 2021).

→ Risk-factor treatment generally not recommended; lifestyle advice.

Age-dependent: high if under 50, low-to-moderate if 50–69 2.5–4.99

SCORE2 2.5 to < 5 %: high risk at age 40–49 (2.5 to < 7.5 %); low-to-moderate at age 50–69 (< 5 %) (ESC 2021).

→ Under 50: risk-factor treatment should be considered. Age 50–69: generally not recommended.

High risk (all ages 40–69) 5–7.49

SCORE2 5 to < 7.5 %: high risk at any age 40–69 (ESC 2021).

→ Risk-factor treatment should be considered, taking risk modifiers, comorbidity, lifetime benefit and patient preference into account.

Age-dependent: very high if under 50, high if 50–69 7.5–9.99

SCORE2 7.5 to < 10 %: very high risk at age 40–49 (≥ 7.5 %); high risk at age 50–69 (5 to < 10 %) (ESC 2021).

→ Under 50: risk-factor treatment is recommended. Age 50–69: should be considered.

Very high risk (all ages 40–69) 10–100

SCORE2 10 % or more: very high risk at any age 40–69 (ESC 2021).

→ Risk-factor treatment is recommended (ESC 2021).

Interpretation bands for the SCORE2. Apply clinical judgement and local guidance.

SCORE2 working group and ESC Cardiovascular Risk Collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur Heart J. 2021;42(25):2439-2454.
Visseren FLJ, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227–3337.

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Pathways

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.