GnRH antagonist
Ganirelix
Brand names: Orgalutran, Fyremadel
Adult dose
Dose: 0.25mg SC OD from day 5–6 of stimulation until day of hCG trigger
Route: SC
Frequency: OD
Clinical pearls
- Prevents premature LH surge during controlled ovarian stimulation
Contraindications
- Pregnancy/breastfeeding
- Severe renal/hepatic impairment
- Postmenopause
Side effects
- Local reactions
- Headache
- Nausea
- OHSS
Reference: BNF; NICE CG156; https://bnf.nice.org.uk/drugs/ganirelix/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21