GnRH antagonist
Linzagolix
Brand names: Yselty
Adult dose
Dose: 100mg or 200mg PO OD ± hormone add-back per indication
Route: PO
Frequency: OD
Clinical pearls
- Moderate-severe symptoms of uterine fibroids
- DEXA before and after prolonged use; co-prescribe oestradiol/norethisterone for ≥6-month use
Contraindications
- Pregnancy
- Active osteoporosis
- Severe hepatic impairment
- Undiagnosed vaginal bleeding
Side effects
- Hot flushes
- Headache
- Reduced bone mineral density (dose-dependent)
- Hepatic enzyme rise
Interactions
- Hormonal contraceptives (progestogen-only or non-hormonal preferred)
- CYP3A4 modulators
Monitoring
- DEXA
- LFTs
- BP
Reference: BNF; NICE TA945; SmPC; https://bnf.nice.org.uk/drugs/linzagolix/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21