Antazoline with Xylometazoline

How it works

Antazoline blocks histamine H1 receptors to reduce itch and inflammation, while xylometazoline stimulates alpha-adrenergic receptors to constrict conjunctival vessels and reduce redness.

Prescribing in practice

• Avoid in untreated angle-closure (narrow-angle) glaucoma, as the sympathomimetic component can precipitate an acute attack.
• Limit to short-term use, as prolonged application of the vasoconstrictor can cause rebound conjunctival hyperaemia.
• Use with caution in patients with cardiovascular disease, hypertension or hyperthyroidism.

Monitoring

Monitor symptomatically for resolution of allergic signs and for rebound redness with continued or prolonged use.

Counselling the patient

• Use for only a few days; if symptoms persist, seek further review.
• Remove contact lenses before instilling drops.
• Transient stinging and pupil changes can occur after instillation.

Evidence & guidelines

Combined antihistamine-decongestant eye drops provide established short-term symptomatic relief in allergic conjunctivitis as reflected in current prescribing references.