Diamidine antimicrobial

Propamidine isetionate

Brand names: Brolene, Golden Eye

Propamidine isetionate is a topical antiseptic (aromatic diamidine) used for minor bacterial eye infections such as conjunctivitis and blepharitis.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It is a diamidine antiseptic with antibacterial and some antifungal/antiprotozoal activity, exerting its effect through disruption of microbial cellular processes.

Prescribing in practice

It is intended for minor superficial infections only and is not a substitute for appropriate antimicrobial therapy in sight-threatening infection such as microbial keratitis, which requires urgent specialist assessment.
Local hypersensitivity reactions can occur with use.
Discontinue and seek review if symptoms fail to improve or worsen.

Monitoring

No laboratory monitoring is required; review clinical response and stop if there is no improvement.

Counselling the patient

Use for the short course advised; return if the eye does not improve.
Stop and seek advice if irritation or a rash around the eye develops.
Avoid wearing contact lenses while the eye is infected unless advised otherwise.

Evidence & guidelines

Propamidine is a long-established topical antiseptic for minor ocular infections per current prescribing references.

Reference: NICE CKS; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Curated clinical cross-links plus same-class fallbacks.

Pathways