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Non-selective NSAID

Flurbiprofen

Brand names: Strefen, Froben

Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class used for pain and inflammation in musculoskeletal and rheumatic conditions.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It inhibits cyclo-oxygenase enzymes, reducing prostaglandin synthesis and thereby producing analgesic, anti-inflammatory and antipyretic effects.

Prescribing in practice

  • Like other NSAIDs it carries gastrointestinal, cardiovascular and renal risks, so use the lowest effective dose for the shortest duration, particularly in older patients.
  • Co-prescription of gastroprotection should be considered in those at increased risk of gastrointestinal ulceration or bleeding.
  • Caution is needed with concurrent anticoagulants, antiplatelets and other nephrotoxic or interacting drugs.

Monitoring

Monitor blood pressure and renal function in at-risk patients and remain alert to gastrointestinal symptoms during treatment.

Counselling the patient

  • Take with or after food and report any black stools, vomiting blood or severe indigestion.
  • Tell your clinician if you have heart, kidney or stomach problems before continuing.
  • Avoid combining with other anti-inflammatory painkillers unless advised.

Evidence & guidelines

The gastrointestinal, cardiovascular and renal risks of NSAIDs as a class are well characterised and reflected in MHRA safety advice.

Reference: NICE NG84; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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