Orthopaedics & Trauma Drugs

70 drugs

Quick-reference dosing for 70 orthopaedics & trauma medicines, aligned to current UK formularies. Each entry lists adult, paediatric and (where relevant) neonatal doses, renal and hepatic adjustments, contraindications, key interactions, monitoring and clinical pearls — with the source reference. Always confirm doses against current prescribing references before prescribing.

Alendronic Acid

Bisphosphonate
Amitriptyline (Orthopaedic — Neuropathic Pain)

Tricyclic Antidepressant — Neuropathic Pain Agent
Apixaban (Orthopaedic VTE Prophylaxis)

Direct Oral Anticoagulant — Factor Xa Inhibitor
Aspirin (Orthopaedic VTE Prophylaxis)

Antiplatelet — COX-1 Inhibitor
Baclofen

GABA-B Agonist Muscle Relaxant
Betamethasone Dipropionate

Long-Acting Corticosteroid (Joint Injection)
Bupivacaine (Orthopaedic Nerve Blocks)

Local Anaesthetic — Long-acting Amide
Calcium 1000mg + Colecalciferol 800 units (Calcichew D3 Forte)

Calcium and Vitamin D Supplement
Capsaicin 0.025–0.075% Cream

Topical Analgesic (TRPV1 Agonist)
Cefazolin

First-Generation Cephalosporin (Surgical Prophylaxis)
Cefuroxime 1.5g IV

Second-Generation Cephalosporin
Celecoxib

COX-2 Inhibitor (NSAID)
Ciprofloxacin (Orthopaedic — Gram-negative Osteomyelitis)

Fluoroquinolone Antibiotic
Clindamycin 150–300mg oral / 600mg IV

Lincosamide Antibiotic
Co-amoxiclav (Open Fracture Antibiotic Prophylaxis)

Beta-lactam / Beta-lactamase Inhibitor Combination
Co-codamol 30/500

Compound Analgesic (Paracetamol + Codeine)
Codeine Phosphate (Orthopaedic — Mild-Moderate Pain)

Opioid Analgesic — Weak (Prodrug)
Colchicine

Anti-Inflammatory (Gout)
Dabigatran (Orthopaedic VTE Prophylaxis)

Direct Oral Anticoagulant — Direct Thrombin Inhibitor
Dalteparin (Orthopaedic VTE Prophylaxis)

Anticoagulant — Low Molecular Weight Heparin
Daptomycin (Prosthetic Joint Infections — Gram-positive)

Lipopeptide Antibiotic
Denosumab

Anti-RANKL Monoclonal Antibody
Dexamethasone (Orthopaedic — PONV and Opioid-Sparing)

Corticosteroid — Anti-emetic and Opioid-Sparing
Dexketoprofen (Acute Musculoskeletal Pain)

NSAID — Non-selective COX Inhibitor (S-enantiomer of Ketoprofen)
Diclofenac

NSAID
Duloxetine 30–60mg

SNRI (Serotonin-Noradrenaline Reuptake Inhibitor)
Enoxaparin (Orthopaedic VTE Prophylaxis)

Low Molecular Weight Heparin (LMWH)
Etoricoxib

COX-2 Selective NSAID
Flucloxacillin 1–2g IV

Penicillinase-Resistant Penicillin (Anti-Staphylococcal)
Flurbiprofen

Non-selective NSAID
Fondaparinux (Orthopaedic VTE Prophylaxis)

Anticoagulant — Selective Factor Xa Inhibitor (Synthetic Pentasaccharide)
Gabapentin

Anticonvulsant / Neuropathic Pain
Gentamicin (Orthopaedic — Bone Cement and Systemic)

Aminoglycoside Antibiotic
Glucosamine

Nutraceutical / supplement
Hyaluronic Acid (Viscosupplementation)

Viscosupplement — Intra-articular Injection
Ibandronate

Bisphosphonate (Osteoporosis)
Ibuprofen (Orthopaedic Musculoskeletal Pain)

NSAID — Non-selective COX Inhibitor
Indomethacin

Non-selective NSAID
Ketamine (Sub-anaesthetic — Orthopaedic Pain)

NMDA Receptor Antagonist — Opioid-Sparing Analgesic
Ketoprofen

Non-selective NSAID
Ketorolac Trometamol

NSAID (Parenteral)
Lidocaine (IV — Regional Anaesthesia)

Local Anaesthetic (Amide)
Lidocaine 5% Medicated Plaster

Topical Local Anaesthetic (Neuropathic Pain)
Linezolid (MRSA Osteomyelitis)

Oxazolidinone Antibiotic
Meropenem (Multi-resistant Gram-negative Bone Infections)

Carbapenem Antibiotic
Methocarbamol

Centrally Acting Skeletal Muscle Relaxant
Methylprednisolone Acetate 40–80mg (Depo-Medrone)

Corticosteroid (Intra-articular)
Morphine (Orthopaedic Acute Pain)

Opioid Analgesic — Strong
Naproxen

NSAID
Nitrous Oxide (Entonox)

Inhalational Analgesic
Oxycodone (Orthopaedic Post-operative Pain)

Opioid Analgesic — Strong
Pamidronate Disodium

IV Bisphosphonate (Paget's Disease / Bone Metastases / Hypercalcaemia)
Paracetamol IV (Orthopaedic — Opioid-Sparing)

Non-opioid Analgesic — Antipyretic
Piperacillin-Tazobactam (Polymicrobial Open Fracture Infections)

Extended-spectrum Beta-lactam / Beta-lactamase Inhibitor
Pregabalin

Anticonvulsant / Neuropathic Pain
Raloxifene

Selective Oestrogen Receptor Modulator (SERM) — Osteoporosis
Rifampicin 300–600mg BD

Rifamycin Antibiotic (Anti-Biofilm)
Rivaroxaban (VTE Prophylaxis — Orthopaedic)

Factor Xa Inhibitor (DOAC)
Romosozumab

Anti-Sclerostin Monoclonal Antibody — Anabolic Osteoporosis Treatment
Ropivacaine (Orthopaedic Nerve Blocks)

Local Anaesthetic — Long-acting Amide (S-enantiomer)
Strontium Ranelate

Antiresorptive and Anabolic Osteoporosis Treatment (RANK/Wnt modulator)
Tapentadol

Dual-Mechanism Opioid Analgesic (MOR + NRI)
Teicoplanin (Orthopaedic Bone and Joint Infections)

Glycopeptide Antibiotic
Teriparatide

Parathyroid Hormone Analogue (Anabolic Bone Agent)
Tizanidine

Centrally Acting Muscle Relaxant (Alpha-2 Agonist)
Tramadol 50–100mg

Opioid Analgesic (Weak) / SNRI
Tranexamic Acid 1g IV

Antifibrinolytic Agent
Triamcinolone Acetonide 10–40mg (Kenalog)

Corticosteroid (Intra-articular / Soft Tissue)
Vancomycin (Orthopaedic Bone and Joint Infections)

Glycopeptide Antibiotic
Zoledronic Acid

Bisphosphonate