PARP inhibitor
Olaparib (Specialist drug)
Brand names: Lynparza
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: BD
Clinical pearls
- BRCA-mutated ovarian, breast, pancreatic, prostate cancers
- Specialist oncology
Contraindications
- Severe hepatic impairment
- Pregnancy
Side effects
- Anaemia
- Cytopenias
- MDS / AML (rare, prolonged use — black box)
- Pneumonitis
- GI upset
- VTE
Interactions
- Strong CYP3A4 modulators
- Anticoagulants
- Hormonal contraceptives
Monitoring
- FBC
- LFTs
- Pulmonary symptoms
- Pregnancy testing
Reference: BNF; multiple NICE TAs; SmPC; https://bnf.nice.org.uk/drugs/olaparib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
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