PARP inhibitor
Talazoparib (Specialist drug)
Brand names: Talzenna
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- BRCA-mutated HER2-negative metastatic breast cancer
- Specialist oncology
Contraindications
- Pregnancy
- Hypersensitivity
Side effects
- Cytopenias (severe)
- MDS/AML (rare)
- Pneumonitis
- Fatigue
- GI upset
Interactions
- P-gp inhibitors
- BCRP inhibitors
Monitoring
- FBC
- LFTs
Reference: BNF; NICE TA760; SmPC; https://bnf.nice.org.uk/drugs/talazoparib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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