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NSAID

Tiaprofenic acid

Brand names: Surgam

Adult dose

Dose: 300mg PO BD or 200mg TDS

Route: PO

Frequency: BD-TDS

Clinical pearls

MHRA: warn re severe cystitis — discontinue if urinary symptoms
Largely avoided

Contraindications

Active peptic ulcer
Severe HF
Severe renal impairment
Bladder/prostate disease
Recurrent UTI
Pregnancy (3rd trimester)
NSAID asthma

Side effects

Severe cystitis (notable signal)
GI bleeding
Renal impairment
CV events

Interactions

Anticoagulants
Methotrexate
Lithium
ACEi/ARB

Monitoring

Urinary symptoms
U&E
BP

Reference: BNF; MHRA; https://bnf.nice.org.uk/drugs/tiaprofenic-acid/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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