Sclerosant
Lauromacrogol 400 (polidocanol)
Brand names: Fibro-Vein, Sclerovein
Adult dose
Dose: 0.5–3% solution per varicose vein/diameter — specialist
Route: Intravenous (sclerotherapy)
Frequency: per session
Clinical pearls
- Sclerotherapy of varicose veins; specialist setting
Contraindications
- Acute thrombophlebitis
- Severe peripheral vascular disease
- Hypersensitivity
Side effects
- Local pain
- Hyperpigmentation
- DVT
- Anaphylaxis
- Skin necrosis at extravasation
Interactions
- COC (relative — VTE risk)
Reference: BNF; NICE CG168; https://bnf.nice.org.uk/drugs/lauromacrogol-400/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Peripheral Arterial Disease · NICE NG19 2012 / ESVS 2017
- Carotid Artery Disease · NICE CG68 / ESVS 2018
- Varicose Veins Management · NICE CG168 2013
- Venous Leg Ulcer Management · NICE NG204 2022
- Major Trauma — Primary Survey (ATLS) · ATLS 10th Edition; JRCALC; NICE NG39
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines