Skip to content
ClinCalc Pro
Menu
Calculators Drugs Pathways AI Dx Donate Get the App
Sclerosant

Lauromacrogol 400 (polidocanol)

Brand names: Fibro-Vein, Sclerovein

Lauromacrogol 400 (polidocanol) is a sclerosant used to treat varicose veins, smaller varicosities and telangiectasia.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

Injected into the vein it damages the endothelium, triggering localised thrombosis and fibrosis that obliterates the vessel lumen.

Prescribing in practice

  • Anaphylaxis and accidental intra-arterial injection causing tissue necrosis are recognised serious hazards; ensure resuscitation facilities and correct technique.
  • It is contraindicated in acute deep vein thrombosis and in patients confined to bed; administration should be by an experienced operator.
  • It is also available as a foam preparation for larger veins, which alters its distribution and efficacy.

Monitoring

Observe the patient for allergic reaction after injection and review the treated limb for thrombophlebitis or skin changes.

Counselling the patient

  • Wear compression as directed after treatment and stay mobile.
  • Report leg swelling, breathlessness or chest pain urgently as these may indicate a clot.

Evidence & guidelines

Sclerotherapy with polidocanol is an established option for varicose veins and telangiectasia, reflected in NICE guidance on varicose vein management (CG168).

Reference: NICE CG168; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

Calculators
Drugs
Pathways