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Vasoactive Intestinal Peptide (VIP) + Alpha-Adrenoceptor Antagonist (Intracavernosal Erectile Dysfunction)

Aviptadil with Phentolamine Mesilate

Brand names: Invicorp

Aviptadil with phentolamine mesilate is a combination intracavernosal injection used in the treatment of erectile dysfunction, typically when oral therapy is unsuitable or ineffective.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

Aviptadil (a vasoactive intestinal polypeptide analogue) and phentolamine (an alpha-adrenoceptor antagonist) together promote cavernosal smooth muscle relaxation and increased arterial inflow, producing an erection.

Prescribing in practice

  • Prolonged erection and priapism can occur and require prompt treatment to avoid permanent erectile tissue damage.
  • The first dose should be given under supervision so that the patient can be taught correct self-injection technique.
  • Avoid in conditions predisposing to priapism and in penile anatomical abnormalities or implants.

Monitoring

Monitor for prolonged erection, injection-site reactions and penile fibrosis with continued use.

Counselling the patient

  • Seek urgent medical help for any erection lasting longer than the time advised by your clinician.
  • Use correct aseptic self-injection technique and rotate the injection site as instructed.

Evidence & guidelines

Intracavernosal therapy for erectile dysfunction is an established second-line option supported by clinical use and the SPC.

Reference: NICE CKS Erectile dysfunction (2023); EAU Guidelines on Sexual and Reproductive Health (2024); Confirm identity and dosing against the manufacturer SPC (eMC) and NICE. Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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