Haematology B

Corrected Count Increment (CCI) for Platelet Transfusion

Assesses response to platelet transfusion. CCI <5,000–7,500 at 1 hour OR <4,500 at 18–24 hours indicates platelet refractoriness.

Used in: Anaemia

Score interpretation

Platelet Refractoriness ≥ 0

CCI <5,000 — platelet refractoriness confirmed. Response inadequate.

→ Investigate for HLA antibodies, HPA antibodies. Consider HLA-matched or crossmatch-compatible platelets. Haematology review.

Borderline Response ≥ 5000

CCI 5,000–7,500 — borderline. Confirm with repeat measurement.

→ Reassess clinically. Check for fever, sepsis, splenomegaly, DIC (non-immune causes of poor increment).

Adequate Response ≥ 7500

CCI ≥7,500 — adequate platelet increment.

→ Transfusion successful. Continue as per clinical protocol.

Interpretation bands for the CCI Platelet. Apply clinical judgement and local guidance.

Hod E, Schwartz J. Platelet transfusion refractoriness. Br J Haematol. 2008;142(3):348-360.
BCSH Guidelines for the use of platelet transfusions. Br J Haematol. 2003;122(1):10-23.

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Pathways

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.