Haematology B

Corrected Count Increment (CCI) for Platelet Transfusion

Assesses response to platelet transfusion. CCI <5,000–7,500 at 1 hour OR <4,500 at 18–24 hours indicates platelet refractoriness.

Used in: Anaemia

Score interpretation

1-Hour CCI < 5000 — Poor Increment ≥ -999999

Poor 1-hour increment. Refractoriness needs poor increments after two consecutive transfusions.

→ Repeat with a 10–60 minute post-transfusion count. If repeated: look for non-immune causes (fever, sepsis, splenomegaly, DIC, bleeding, drugs) and, if none, test for HLA/HPA antibodies and discuss HLA-matched or crossmatched platelets with haematology.

1-Hour CCI 5000–7499 — Borderline ≥ 5000

Borderline 1-hour increment.

→ Reassess clinically and repeat with the next transfusion. Check for fever, sepsis, splenomegaly and DIC (non-immune causes of poor increment).

1-Hour CCI ≥ 7500 — Adequate Increment ≥ 7500

Adequate 1-hour platelet increment.

→ Transfusion response adequate. Continue as per clinical protocol.

Interpretation bands for the CCI Platelet. Apply clinical judgement and local guidance.

References

Hod E, Schwartz J. Platelet transfusion refractoriness. Br J Haematol. 2008;142(3):348-360.
BCSH Guidelines for the use of platelet transfusions. Br J Haematol. 2003;122(1):10-23.

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Pathways

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.

Score interpretation

References

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