Rai Staging System for CLL
Rai staging system for Chronic Lymphocytic Leukaemia (CLL) classifying disease into stages 0–IV based on lymphocytosis, organomegaly, and cytopenias.
Score interpretation
→ Rai Stage IV: Thrombocytopenia present. High-risk CLL. Median survival ~19 months (historical). Refer for treatment consideration.
→ Rai Stage III: Anaemia present. High-risk CLL. Median survival ~19 months (historical). Early treatment initiation usually indicated.
→ Rai Stage II: Splenomegaly/hepatomegaly. Intermediate-risk CLL. Median survival ~7 years. Treatment when symptomatic or IWCLL criteria met.
→ Rai Stage I: Lymphadenopathy only. Intermediate-risk CLL. Median survival ~9 years. Watch and wait unless symptomatic.
→ Rai Stage 0: Lymphocytosis only. Low-risk CLL. Median survival ~>10 years. Watch and wait strategy; no treatment needed.
Interpretation bands for the Rai CLL Staging. Apply clinical judgement and local guidance.
References
Related
Curated clinical cross-links plus same-class fallbacks.
- Fong Clinical Risk Score for Colorectal Cancer Recurrence · Oncology
- CRASH Score for Chemotherapy Risk Assessment in Elderly Patients · Oncology
- Ann Arbor Staging System for Lymphoma · Oncology
- Follicular Lymphoma International Prognostic Index (FLIPI) · Oncology
- International Staging System for Multiple Myeloma (ISS) · Oncology
- CISNE Score for Febrile Neutropenia · Oncology
- Omalizumab (Dermatology — Chronic Urticaria) · Anti-IgE Monoclonal Antibody
- Zoledronic Acid · Bisphosphonate (IV)
- Denosumab · RANK Ligand Inhibitor (Anti-resorptive)
- Zoledronic Acid · IV Bisphosphonate
- Fentanyl Transdermal Patch (Elderly Chronic Pain) · Opioid Analgesic — Transdermal Patch
- Morphine Slow-Release (Elderly Chronic Pain) · Opioid Analgesic — Modified-Release Oral
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.