haematology
Multiple Myeloma Diagnostic Criteria (CRAB + SLiM-CRAB)
IMWG 2014 diagnostic criteria for multiple myeloma. Clonal bone marrow plasma cells >= 10% PLUS CRAB features (hyperCalcaemia, Renal failure, Anaemia, Bone lesions) OR biomarkers defining malignancy (SLiM criteria).
References
- Rajkumar SV et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12):e538-548.
- NICE NG35. Myeloma: diagnosis and management. NICE. 2016 (updated 2022).
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
- Gelatin (succinylated) · Colloid plasma volume expander
- Lanadelumab · Anti-plasma kallikrein monoclonal antibody
- Sodium Cromoglicate Nasal Spray · Mast Cell Stabiliser — Allergic Rhinitis
- Olopatadine · H1 antihistamine + mast cell stabiliser
- C1-esterase inhibitor · Plasma-derived complement inhibitor
- Berotralstat · Oral plasma kallikrein inhibitor
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.