Lodoxamide

The page is Lodoxamide, brand Alomide, topical ophthalmic mast cell stabiliser, ophthalmology — and the recovered source is the UK SPC for Alomide 0.1% w/v Eye Drops Solution, i.e. the page's own named brand and formulation. Indication (allergic conjunctivitis), route (topical ophthalmic) and population all match, so the §4.2 dose has been extracted. REGULARITY MATTERS (§4.2, verbatim): 'Patients should be advised that the effect of ALOMIDE therapy is dependent upon its administration at regular intervals, as directed.' TIME TO EFFECT (§4.2, verbatim): 'Improvements in signs and symptoms in response to ALOMIDE therapy (decreased discomfort, itching, foreign body sensation, photophobia, acute ocular pain, tearing, discharge, erythema/swelling, conjunctival redness, limbal reaction, epithelial disease, ptosis) are usually evident within a few days, but longer treatment for up to four weeks is sometimes required. Once symptomatic improvement has been established, therapy should be continued for as long as needed to sustain improvement.' INITIAL DISCOMFORT (§4.2, verbatim): 'Patients should also be advised that instillation of eye drops in allergic conjunctivitis may cause discomfort initially and that this will decline with improvement of the disease.' TECHNIQUE (§4.2, verbatim): 'Nasolacrimal occlusion or gently closing the eyelid after administration is recommended. This may reduce the systemic absorption of medicinal products administered via the ocular route and result in a decrease in systemic adverse reactions.' ELDERLY (§4.2, verbatim): 'There are no special precautions to be followed in prescribing ALOMIDE for the elderly.' CONCOMITANT STEROID (§4.2, verbatim): 'If required, corticosteroids may be used concomitantly with ALOMIDE.' CONTACT LENSES (§4.4): ALOMIDE contains 0.7 mg benzalkonium chloride in each 10 ml, equivalent to 0.07 mg/ml; 'Patients must be instructed to remove contact lenses prior to application of ALOMIDE and wait at least 15 minutes before reinsertion.' OTHER EYE DROPS (§4.5, verbatim): 'If more than one topical ophthalmic medicinal product is being used, the medicines must be administered at least 5 minutes apart. Eye ointments should be administered last.'

NOT WEIGHT-BASED — dosePerKg is deliberately null because this SPC expresses the dose as a fixed number of drops, not per kilogram. Do not derive a per-kg figure. §4.2 doses adults and children together, verbatim: 'Adults and children: One or two drops in each eye four times a day at regular intervals.' AGE FLOOR, verbatim: 'Children less than 4 years: The safety and effectiveness of ALOMIDE in children below the age of four years have not been established.' No dose is available from this source for a child under 4 years.